本周推荐（40）
| 01月 18th, 2008 | by zhongtiannongmin |
(1 votes, average: 5 out of 5)
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Carlos E. Harjes, Torbert R. Rocheford, Ling Bai, Thomas P.
Brutnell, Catherine Bermudez Kandianis, Stephen G. Sowinski, Ann E.
Stapleton, Ratnakar Vallabhaneni, Mark Williams, Eleanore T.
Wurtzel, Jianbing Yan, and Edward S. Buckler
Science 18 January 2008: 330-333.
http://www.sciencemag.org/cgi/content/abstract/319/...
这是差点被当作封面的图片:-)
这篇文章有意思的地方在于：对一个QTL（这个QTL控制PRO-VA的含量）进行了克隆验证，这个克隆不是传统意义的图位，或者转座子的方法，而是结合关联分析，连锁分析，表达分析和突变体分析多方验证。
其有意义的地方在于为解决VAD(vitamin A
deficiency)提供了一条新的途径。文章中开发的3个功能分子标记，很容易用于分子标记辅助育种研究，而事实上，包括illions
大学，CIMMYT和中国农业大学在内的多家机构已经在用这些标记进行VA的MAS研究。关于MAS，正是我以后要谈的。。。
这是刚刚收到的BBC的报道：
A team of
American researchers has developed an economical approach on the
selective breeding of maize with increased levels of vitamin A
precursors. Maize is an essential part of diets of millions of
people around the world, especially in the sub-Saharan Africa.
Improving the vitamin A content of maize may help enhance the
nutritional status of millions of people from the developing world.
Dietary vitamin A deficiency is estimated to cause eye disease in
40 million children each year and places 140 to 250 million at risk
for health disorders.
The
scientists employed a technique called quantitative trait loci
(QTL) mapping, to identify specific regions in the maize genome
that influence the production of vitamin A precursors. They also
used association and linkage mapping, which involve studying
specific gene sequences and tracking their inheritance pattern, to
determine which gene coincides with increased provitamin A levels.
They discovered that variations in a specific locus (site in a
chromosome) alter the cascade of chemical reactions that produce
vitamin A precursors. Selection of favorable form of this locus, by
marker assisted selection, may enable developing-country breeders
to effectively produce maize grain with higher provitamin A
levels.
Read more
at http://www.news.uiuc.edu/news/08/0117maize.html
The abstract of the paper published by the journal Science is
available at http://www.sciencemag.org/cgi/content/abstract/319/5861/330
审稿人几尽溢美之辞，而没有任何重大修改就接受了改文章：
This manuscript describes a thorough, innovative
and compelling study combining a variety of molecular genetic
techniques ……The study is an early and outstanding
example of the use of association mapping in plants and the problem
that the work is directed at, provitamin A content of world staple
crops, could not be of higher significance, relevance or
importance. ……